Vaibhav Upadhyay

Shifts in the human gut microbiome during cancer chemotherapy are diet-dependent

This study shows diet changes during cancer chemotherapy affect gut microbiome composition and diversity, with specific nutrients linked to microbial shifts and toxicity.

Female-enriched Eggerthella lenta drives neuroinflammation and IFN-γ via host receptor TLR2

The paper identifies a female-enriched gut bacterium, Eggerthella lenta, that drives neuroinflammation and IFN-γ via TLR2 in autoimmune disease models.

Gut bacterial lactate stimulates lung epithelial mitochondria and exacerbates acute lung injury

This study shows gut bacteria produce lactate that increases lung epithelial mitochondrial activity and worsens acute lung injury.

Expansion of a bacterial operon during cancer treatment ameliorates drug toxicity

The paper shows that a bacterial operon in the gut microbiome can reduce drug toxicity during cancer treatment by inactivating 5-fluorouracil.

Cell type specificity of mosaic chromosome 1q gain resolved by snRNA-seq in a case of epilepsy with hyaline protoplasmic astrocytopathy

The paper uses snRNA-seq to analyze mosaic chromosome 1q gain in a case of epilepsy with hyaline protoplasmic astrocytopathy, finding cell-type-specific gene expression changes in neurons and astrocytes.

PhIP-Seq uncovers novel autoantibodies and unique endotypes in interstitial lung disease

This study uses PhIP-Seq to identify novel autoantibodies in ILD patients, revealing a new molecular endotype associated with inflammation and fibrosis.