Elevated mitochondrial metabolism in Down syndrome iPSCs reduces commitment to neuroectoderm
Malay Chaklader, Guilherme Henrique Souza Bomfim, Jiankun Zhu, Neil Jeju, Théodore Nguyen, Yingli Duan, Brian F. Niemeyer, Joaquin Maximiliano Espinosa, Edwin Rosado-Olivieri, Weichun Lin, Rodrigo S. Lacruz, Beverly A. Rothermel
This study shows that increased mitochondrial metabolism in Down syndrome iPSCs impairs neuroectoderm commitment by reducing ciliation, and this effect can be reversed by inhibiting mitochondrial calcium uptake.
EMBO Reports · Oct 30, 2026Peer-reviewedDevelopmental Biology