Author

Malay Chaklader

The University of Texas Southwestern Medical CenterORCID 0000-0003-2192-7537Unclaimed ORCID profile · follow to get notified of new preprints

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Developmental Biology· 1

Signature Assays, Organisms & Methods

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Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Beverly A. RothermeliD· 1 shared Brian F. NiemeyeriD· 1 shared Edwin Rosado-Olivieri· 1 shared Guilherme Henrique Souza BomfimiD· 1 shared Jiankun Zhu· 1 shared Joaquin Maximiliano EspinosaiD· 1 shared Neil JejuiD· 1 shared Rodrigo S. LacruziD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperDevelopmental Biology

Beverly A. RothermelORCID

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1 paper

Recent·Most cited

Developmental BiologyEMBO ReportsPeer-reviewedOct 30, 2026

Elevated mitochondrial metabolism in Down syndrome iPSCs reduces commitment to neuroectoderm

Malay Chaklader, Guilherme Henrique Souza Bomfim, Jiankun Zhu…·Beverly A. Rothermel

This study shows that increased mitochondrial metabolism in Down syndrome iPSCs impairs neuroectoderm commitment by reducing ciliation, and this effect can be reversed by inhibiting mitochondrial calcium uptake.

1 citation

humanATAC-seq

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