Beverly A. Rothermel

This study shows that increased mitochondrial metabolism in Down syndrome iPSCs impairs neuroectoderm commitment by reducing ciliation, and this effect can be reversed by inhibiting mitochondrial calcium uptake.

This study shows that tumor-secreted GDF15 drives cachexia in STK11/LKB1-mutated NSCLC, and blocking GDF15 reduces cachexia symptoms in mice.