ER stress and cell fate: FKBP2 regulates proinsulin folding and α- vs. β-cell differentiation via NFAT and HDAC9
Edyta Urbaniak, Maja Baginska, Wojciech J. Szlachcic, Małgorzata Grabowska, Ekaterina Shcheglova, Artur Jankowski, Michał Marzec, Malgorzata Borowiak
This study identifies FKBP2 as a regulator of proinsulin folding and β-cell differentiation through NFAT and HDAC9, revealing its role in ER stress and diabetes pathogenesis.
bioRxiv · Sep 1, 2025 · PreprintCell Biology