Theodore dos Santos

Supervised machine learning identifies impaired mitochondrial quality control in β cells with development of type 2 diabetes

The paper uses supervised machine learning to identify impaired mitochondrial quality control in β cells associated with type 2 diabetes using single-cell RNA sequencing data.

Molecular Correlates of Glycine Receptor Activity in Human β Cells

This study investigates GlyR dysfunction in T2D and high glucose conditions, finding reduced GlyR currents and gene expression, but no splicing changes, and links GlyR activity to gene regulatory networks.

TMEM55A-mediated PI5P signaling regulates α-cell actin depolymerization and glucagon secretion

This study identifies TMEM55A as a regulator of α-cell exocytosis and glucagon secretion through PI5P signaling and F-actin remodeling in response to oxidative stress.

Linking molecular pathways and islet cell dysfunction in human type 1 diabetes

This study investigates islet cell dysfunction in type 1 diabetes by integrating electrophysiological, transcriptomic, and machine learning analyses of human islet cells from T1D donors.

HumanIslets: An integrated platform for human islet data access and analysis

HumanIslets.com provides an open platform for accessing and analyzing human islet data, enabling research on diabetes through integrated molecular and cellular phenotyping.

FK506-binding protein 2 participates in proinsulin folding

This study identifies FKBP2 as a proline isomerase involved in proinsulin folding, showing its role in preventing misfolding and apoptosis in β-cells.

Integration of single-cell multiomic measurements across disease states with genetics identifies mechanisms of beta cell dysfunction in type 2 diabetes

The paper integrates single-cell multiomic data with genetics to identify gene regulatory changes in beta cells associated with type 2 diabetes.