ImmunologybioRxivPreprint
Endosome dysfunction leads to gain-of-function TLR7 and human lupus
Harshita Mishra, Claire Schlack-Leigers, Ee Lyn Lim…·Olivia Majer
This study shows that endosome dysfunction causes TLR7 gain-of-function and contributes to human lupus by disrupting TLR7 turnover and leading to self-reactivity.
DOI 10.1101/2023.04.03.535356