Oxygen-independent, hormonal control of HIF-1α regulates the developmental and regenerative growth of cardiomyocytes.
Amarylis Claudine Bonito Azeredo Wanschel, Angeliki Daiou, Jeffim N. Kuznetsoff, Stefan Kurtenbach, Katerina Petalidou, Thomai Mouskeftara, Helen Gika, Daniel A. Rodriguez, Eleftherios I. Papadopoulos, Georgios Siokatas, Polyxeni P. Sarri, Kyriaki Karava, Efthimios Tsivoglou, Christine Kottaridi, Alessandro Gonzalez Salerno, , Joshua M. Hare
This paper identifies an O2-independent HIF-1 mechanism regulated by GH/IGF1/SST signaling that controls cardiomyocyte growth through metabolic shifts.
bioRxiv · Jan 31, 2022 · PreprintDevelopmental Biology