Stefan Kurtenbach

LMNA Haploinsufficiency in Human iPSC-Derived Cardiac Organoids Reveals Early Fibrotic Signaling as a Therapeutically Targetable Process

This study uses cardiac organoids derived from patient iPSCs to show that LMNA haploinsufficiency causes early fibrotic signaling, which can be targeted by antifibrotic drugs.

Cardiomyocyte-specific expression of HIF-1α mediates the cardioprotective effects of Growth Hormone-Releasing Hormone (GHRH)

This study identifies the HIF-1 pathway as mediating the cardioprotective effects of GHRH-agonists in a murine model of cardiometabolic HFpEF.

Identification of targetable epigenetic vulnerabilities for uveal melanoma

This study identifies BET inhibition as a promising therapeutic strategy for uveal melanoma by demonstrating its efficacy in reducing metastasis and improving survival in a mouse model.

GDF15 reprograms the microenvironment to drive the development of uveal melanoma liver metastases

This study identifies GDF15 as a driver of uveal melanoma liver metastasis by reprogramming hepatic stellate cells to promote angiogenesis and matrix deposition.

Oxygen-independent, hormonal control of HIF-1α regulates the developmental and regenerative growth of cardiomyocytes.

This paper identifies an O2-independent HIF-1 mechanism regulated by GH/IGF1/SST signaling that controls cardiomyocyte growth through metabolic shifts.

UPhyloplot2: Visualizing Phylogenetic Trees from Single-Cell RNA-seq Data

UPHyloplot2 generates phylogenetic plots from inferCNV output files to visualize tumor clonality inferred from single-cell RNA-seq data.

PieParty: Visualizing cells from scRNA-seq data as pie charts

PieParty visualizes scRNA-seq data as pie charts where each cell's slices represent gene expression, enabling intuitive and dense visualization of multiple genes and networks.

SparK: A Publication-quality NGS Visualization Tool

Command-line Python tool that turns sequencing tracks into editable vector figures, averaging replicates, drawing standard-deviation tracks and marking significantly changed regions.