CellPHIE: Integrating Pathway Discovery With Pooled Profiling of Perturbations Uncovers Pathways of Huntington's Disease, Including Genetic Modifiers of Neuronal Development and Morphology
Byunguk Kang, Michael A. Murphy, Christopher Ng, Matthew Joseph Leventhal, Nhan C. Huynh, Egun Im, Serwah A. Danquah, David E. Housman, Ralda Nehme, Samouil L. Farhi, Ernest Fraenkel
The paper integrates pathway discovery with pooled genetic perturbation to identify modifiers of Huntington's disease, revealing genes involved in neuronal development and morphology.
bioRxiv · Feb 19, 2025 · PreprintNeuroscience