Matthew Joseph Leventhal

An integrative systems-biology approach defines mechanisms of Alzheimer's disease neurodegeneration

This study integrates multi-omics data from Drosophila and human Alzheimer's disease models to identify pathways involved in neurodegeneration.

Intersecting impact of CAG repeat and Huntingtin knockout in stem cell-derived cortical neurons

This study compares the effects of HTT knockout and CAG repeat expansion in cortical neurons, identifying shared and distinct biological pathways involved in HD.

CellPHIE: Integrating Pathway Discovery With Pooled Profiling of Perturbations Uncovers Pathways of Huntington's Disease, Including Genetic Modifiers of Neuronal Development and Morphology

The paper integrates pathway discovery with pooled genetic perturbation to identify modifiers of Huntington's disease, revealing genes involved in neuronal development and morphology.

Chromosomal rearrangements and instability caused by the LINE-1 retrotransposon

This study uses whole-genome sequencing to show that LINE-1 retrotransposition directly causes chromosomal rearrangements and instability in cancer genomes.

Transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a Drosophila knock-in tauopathy model

This study creates a Drosophila tauopathy model with the P251L mutation and uses single-cell RNA sequencing to identify molecular changes in neuronal and glial cells.

Integrative analysis reveals a conserved role for the amyloid precursor protein in proteostasis during aging

The paper identifies a conserved role for APP in proteostasis during aging through genetic and multi-omics analyses in Drosophila and human models.

Inherited Causes of Clonal Hematopoiesis of Indeterminate Potential in TOPMed Whole Genomes

The paper identifies germline genetic variants associated with clonal hematopoiesis of indeterminate potential (CHIP) using whole genome sequences from the TOPMed program.