Author

David E. Housman

Massachusetts Institute of TechnologyORCID 0000-0001-5016-0756Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:CRISPR screen· 1 Organism:mouse· 1 Organism:multiple species· 1 Research Focus:perturbation response prediction· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Christopher NgiD· 2 shared Ahmad Al KhleifatiD· 1 shared Alan Michael PittmaniD· 1 shared Aleksey ShatunoviD· 1 shared Alina L. Li· 1 shared Ammar Al‐ChalabiiD· 1 shared Ann M. GraybieliD· 1 shared Anne C. Smith· 1 shared

Activity by Year

2017-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersNeuroscience

Christopher NgORCID

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Author profile →

3 papers

Recent·Most cited

NeurosciencebioRxivPreprintFeb 19, 2025

CellPHIE: Integrating Pathway Discovery With Pooled Profiling of Perturbations Uncovers Pathways of Huntington's Disease, Including Genetic Modifiers of Neuronal Development and Morphology

Byunguk Kang, Michael A. Murphy, Christopher Ng…·Ernest Fraenkel

The paper integrates pathway discovery with pooled genetic perturbation to identify modifiers of Huntington's disease, revealing genes involved in neuronal development and morphology.

DOI 10.1101/2025.02.19.639023

humanCRISPR screen

𝕏 PostBluesky

NeurosciencebioRxivPreprintJul 22, 2019

Mutations in CalDAG-GEFI Lead to Striatal Signaling Deficits and Psychomotor Symptoms in Multiple Species Including Human

Jill R. Crittenden, Magdalena M. Sauvage, Takashi Kitsukawa…·Ann M. Graybiel

This study identifies CalDAG-GEFI mutations causing psychomotor symptoms and bleeding in multiple species, revealing conserved signaling deficits in striatal function.

6 citations

humanmouse

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BioinformaticsGenome ResearchPeer-reviewedNov 1, 2017

Detection of long repeat expansions from PCR-free whole-genome sequence data

Egor Dolzhenko, Joke J.F.A. van Vugt, Richard J. Shaw…·Michael A. Eberle

The paper introduces ExpansionHunter, a tool for detecting long repeat expansions from PCR-free WGS data, achieving high sensitivity and specificity in identifying pathogenic expansions.

388 citations

humanwhole-genome sequencing

𝕏 PostBluesky