From iPSCs to NPCs to cortical neurons: bioenergetic, neuronal, and calcium signaling phenotypes in bipolar disorder with and without familial mitochondrial disease
Dana El Soufi El Sabbagh, Jaehyoung Choi, Lakshmini Balachandar, Eileen Haydarian, Jude Demyati, Zaara Mazhar, Angela Duong, Chiara C. Bortolasci, Courtney Irwin, Karun Kar Singh, Michael Berk, Ken R. Walder, L Trevor Young, Peter Louis Carlen, Ana C. Andreazza
This study compares neuronal development and function in bipolar disorder with and without familial mitochondrial disease using iPSC-derived neurons.
bioRxiv · Dec 22, 2025 · PreprintNeuroscience