Michael Berk

iPSC-Derived Myotubes from ME/CFS Patients Reveal Signature Genes, Isoforms and Pathways with Drug Repurposing Potential

The paper uses iPSC-derived myotubes from ME/CFS patients and controls to identify differentially expressed genes, isoforms, and pathways, and prioritizes compounds for drug repurposing.

The toll-like receptor signalling pathway is altered in iPSC-derived cortical networks from people with bipolar disorder.

The paper identifies altered toll-like receptor signalling in iPSC-derived cortical networks from bipolar disorder patients using transcriptome sequencing and differential expression analysis.

Structural Brain Network Alterations in Relation to Treatment and Illness Severity in Bipolar Disorder

This study analyzes structural brain network changes in bipolar disorder, finding widespread connectivity disruptions linked to illness severity and medication use.

From iPSCs to NPCs to cortical neurons: bioenergetic, neuronal, and calcium signaling phenotypes in bipolar disorder with and without familial mitochondrial disease

This study compares neuronal development and function in bipolar disorder with and without familial mitochondrial disease using iPSC-derived neurons.

Investigating the role of melatonin in bipolar disorder using transcriptomics

This study uses transcriptomics to investigate melatonin's role in bipolar disorder, finding dysregulated melatonin-related genes and potential therapeutic agents.

iPSC-Derived Cerebral Organoids Reveal Mitochondrial, Inflammatory and Neuronal Vulnerabilities in Bipolar Disorder

This study uses iPSC-derived cerebral organoids to show mitochondrial and inflammatory dysfunctions in bipolar disorder and tests potential therapeutic interventions.

Multiscale heterogeneity of white matter morphometry in psychiatric disorders

The paper examines white matter volume deviations in psychiatric disorders using normative modeling, finding heterogeneous patterns with some aggregation in autism and schizophrenia.

Anti-manic effect of deep brain stimulation of the ventral tegmental area in an animal model of mania induced by methamphetamine

This study investigates the anti-manic effects of VTA deep brain stimulation in a methamphetamine-induced mania model, showing both stimulation patterns reduce hyperlocomotion and modulate dopamine dynamics.

Plasma neurofilament light protein provides evidence of accelerated brain ageing in treatment-resistant schizophrenia

The paper examines if plasma NfL levels correlate with age differently in psychiatric disorders compared to healthy individuals, finding accelerated brain aging in treatment-resistant schizophrenia.

Neurovegetative symptom subtypes in young people with major depressive disorder and their structural brain correlates

The paper identifies neurovegetative symptom subtypes in young people with MDD and finds structural brain correlates in the anterior insula.