Nuclear GAPDH cascade mediates stress-dependent pathological cardiac growth
Shun Nakamura, Manling Zhang, Genri Numata, Taro Kariya, Hideyuki Sasaki, Masayuki Sasaki, Adriana Ramos, Eisuke Amiya, Masaru Hatano, Masahiko Ando, Yoichi Yasunaga, Masaki Iwakiri, Norimichi Koitabashi, Guangshuo Zhu, Tsuyoshi Tsujimura, , Eiki Takimoto
This study identifies nuclear GAPDH translocation as a mediator of stress-induced cardiac hypertrophy through BRG1-associated chromatin remodeling in mice and human patients.
bioRxiv · Nov 20, 2025 · PreprintMolecular Biology