NeuroscienceJournal of Cellular PhysiologyPeer-reviewed
Human neurons lacking amyloid precursor protein exhibit cholesterol-associated developmental and presynaptic deficits
Haylee Mesa, Elaine Y. Zhang, Yingcai Wang, Qi Zhang
This study shows that human neurons lacking APP have developmental and presynaptic deficits that are corrected by cholesterol, suggesting APP's role in maintaining cholesterol homeostasis for brain function.
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