Qi Zhang

Chemical Probing of Diacylglycerol Dynamics at Lipid Droplets

This paper develops a DAG-mimetic fluorescent probe, DONDI-5, to visualize diacylglycerol dynamics at lipid droplets and shows DAGs can be stored there without converting to triacylglycerols.

Synaptic Toxicity of OGA Inhibitors and the Failure of Ceperognastat

This study shows that OGA inhibitors impair synaptic plasticity and cause synaptotoxic effects in mouse hippocampal slices, suggesting potential risks for Alzheimer's disease therapies.

Tardigrade cytoplasmic abundant heat-soluble proteins serve as membrane protectors during dehydration

This study identifies CAHSs as membrane protectors in tardigrades during dehydration, showing they dimerize to form a mesh that reinforces intracellular membranes.

Human neurons lacking amyloid precursor protein exhibit cholesterol-associated developmental and presynaptic deficits

This study shows that human neurons lacking APP have developmental and presynaptic deficits that are corrected by cholesterol, suggesting APP's role in maintaining cholesterol homeostasis for brain function.

Reciprocal Modulation Between Amyloid Precursor Protein and Synaptic Membrane Cholesterol Revealed By Live Cell Imaging

The paper uses live cell imaging to show that APP and synaptic membrane cholesterol levels reciprocally modulate at synaptic boutons.

RNA editing of CAPS1 regulates synaptic vesicle organization, release and retrieval.

This study shows RNA editing of CAPS1 affects synaptic vesicle organization, release, and retrieval by altering protein function in hippocampal neurons.