Haylee Mesa

Chemical Probing of Diacylglycerol Dynamics at Lipid Droplets

This paper develops a DAG-mimetic fluorescent probe, DONDI-5, to visualize diacylglycerol dynamics at lipid droplets and shows DAGs can be stored there without converting to triacylglycerols.

Synaptic Toxicity of OGA Inhibitors and the Failure of Ceperognastat

This study shows that OGA inhibitors impair synaptic plasticity and cause synaptotoxic effects in mouse hippocampal slices, suggesting potential risks for Alzheimer's disease therapies.

Modular Fluorescent Cholesterol Naphthalimide Probes And Their Application For Cholesterol Trafficking Studies In Cells

The paper develops modular fluorescent cholesterol analogs to study subcellular cholesterol trafficking, showing that head group modifications affect internalization efficiency and subcellular distribution.

Human neurons lacking amyloid precursor protein exhibit cholesterol-associated developmental and presynaptic deficits

This study shows that human neurons lacking APP have developmental and presynaptic deficits that are corrected by cholesterol, suggesting APP's role in maintaining cholesterol homeostasis for brain function.