Metabolic Salvage and Acyl-chain Remodeling Support Glycosphingolipid Synthesis within the PDAC Tumor Microenvironment
Anna Trimble, Casie S. Kubota, Elaine Zhao, Maureen L. Ruchhoeft, Jonathan Weitz, Woncheol Jung, Kristina L. Peck, Satoshi Ogawa, Ethan L. Ashley, Hervé Tiriac, Tae Gyu Oh, Andrew M. Lowy, Dannielle D. Engle, Christian M. Metallo
The paper uses 13C metabolic flux analysis on PDAC tumor slice cultures to identify metabolic pathways supporting glycosphingolipid synthesis and highlight the role of PIKfyve in lipid homeostasis.
bioRxiv · May 5, 2026 · PreprintCancer Biology