Tae Gyu Oh

Hepatocyte MLKL Drives Obesity-Driven Hepatocellular Carcinoma Progression via Mitochondrial Dysfunction Independent of Necroptosis in MASLD

This study shows that hepatocyte MLKL promotes obesity-driven MASLD-HCC through mitochondrial dysfunction and MFN2 suppression, independent of necroptosis.

Chronic pancreatitis patient-derived organoids reveal new paths to precision therapeutics

This study uses patient-derived organoids to identify CFTR modulators as a therapeutic strategy for chronic pancreatitis.

HDAC Inhibition Sensitizes Pancreatic Tumors to DNA Damage by Global Redistribution of the Transcriptional Machinery

This study shows HDAC inhibition reduces DDR gene expression in pancreatic tumors by altering transcriptional machinery distribution, enhancing sensitivity to DNA damage, and introduces a nanoparticle delivery system to reduce toxicity.

CA19-9 induces microenvironment remodeling in pancreatic ductal adenocarcinoma

This study identifies CA19-9's role in remodeling the PDAC tumor microenvironment by inducing IL1a and TGFb, leading to immunosuppressive changes that can be mitigated by blocking these factors.

Metabolic Salvage and Acyl-chain Remodeling Support Glycosphingolipid Synthesis within the PDAC Tumor Microenvironment

The paper uses 13C metabolic flux analysis on PDAC tumor slice cultures to identify metabolic pathways supporting glycosphingolipid synthesis and highlight the role of PIKfyve in lipid homeostasis.

Rejuvenation of the Aged Cerebrovascular System via Protein Corona-Guided Fusogenic Liposome Delivery

This paper develops ApoE-functionalized fusogenic liposomes to deliver resveratrol to the brain, improving vascular function and cognitive performance in aged mice with reduced drug dosage.

Neural basis of opioid-induced respiratory depression and its rescue

This study identifies PBLOprm1 neurons as critical for opioid-induced respiratory depression and shows their activation can rescue respiratory rhythms.

Unified neural pathways that gate affective pain and multisensory innate threat signals to the amygdala

The paper identifies unified neural pathways that gate affective pain and multisensory innate threat signals to the amygdala, revealing their role in aversive perception.