Dannielle D. Engle

This study shows HDAC inhibition reduces DDR gene expression in pancreatic tumors by altering transcriptional machinery distribution, enhancing sensitivity to DNA damage, and introduces a nanoparticle delivery system to reduce toxicity.

This study identifies CA19-9's role in remodeling the PDAC tumor microenvironment by inducing IL1a and TGFb, leading to immunosuppressive changes that can be mitigated by blocking these factors.

The paper uses 13C metabolic flux analysis on PDAC tumor slice cultures to identify metabolic pathways supporting glycosphingolipid synthesis and highlight the role of PIKfyve in lipid homeostasis.

This study shows CA19-9 promotes pancreatic cancer liver metastasis via E-selectin-mediated extravasation and AKT signaling, suggesting it as a therapeutic target.

This study identifies metabolic adaptations in pancreatic cancer cells resistant to autophagy inhibitors and shows that targeting pyrimidine salvage can enhance treatment efficacy.