This study identifies a ciliary gene program linked to cognitive resilience in mice, independent of age, by integrating behavioral data with transcriptomic profiling.

bioRxiv · Oct 23, 2026 · PreprintAnimal Behavior & Cognition

CA19-9 induces microenvironment remodeling in pancreatic ductal adenocarcinoma

Jasper Hsu, Hyemin Song, Satoshi Ogawa, Casie S. Kubota, Kristina L. Peck, Emily Jacobs, Lizmarie Garcia-Rivera, Jonathan Zhu, Yuan Sui, Woncheol Jung, Yang Dai, Jan C. Lumibao, Chelsea R. Bottomley, Kassidy Curtis, Mars Bau, , Dannielle D. Engle

This study identifies CA19-9's role in remodeling the PDAC tumor microenvironment by inducing IL1a and TGFb, leading to immunosuppressive changes that can be mitigated by blocking these factors.

bioRxiv · May 26, 2026 · PreprintCancer Biology

Metabolic Salvage and Acyl-chain Remodeling Support Glycosphingolipid Synthesis within the PDAC Tumor Microenvironment

Anna Trimble, Casie S. Kubota, Elaine Zhao, Maureen L. Ruchhoeft, Jonathan Weitz, Woncheol Jung, Kristina L. Peck, Satoshi Ogawa, Ethan L. Ashley, Hervé Tiriac, Tae Gyu Oh, Andrew M. Lowy, Dannielle D. Engle, Christian M. Metallo

The paper uses 13C metabolic flux analysis on PDAC tumor slice cultures to identify metabolic pathways supporting glycosphingolipid synthesis and highlight the role of PIKfyve in lipid homeostasis.

bioRxiv · May 5, 2026 · PreprintCancer Biology

Rejuvenation of the Aged Cerebrovascular System via Protein Corona-Guided Fusogenic Liposome Delivery

Santny Shanmugarama, Till Gronemann, Boglárka Csík, Roland Patai, Ádám Nyúl‐Tóth, Dorina Nagy, László Hricisák, Mark Nagykaldi, Madison Sanford, Raghavendra Yelahanka Nagaraja, Rafał Gulej, Rebeka Kristóf, Kiana Vali Kordestan, Evelyn Brunner, Sharon Negri, , Anna Csiszár

This paper develops ApoE-functionalized fusogenic liposomes to deliver resveratrol to the brain, improving vascular function and cognitive performance in aged mice with reduced drug dosage.

bioRxiv · Mar 9, 2026 · PreprintAnimal Behavior & Cognition