Neuroinflammation plays a critical role in cerebral cavernous malformation disease
Catherine Chinhchu Lai, Bliss Nelsen, Eduardo Frías-Anaya, Helios Gallego-Gutiérrez, Marco Orecchioni, Victoria Herrera, Elan Ortiz, Hao Sun, Omar A. Mesarwi, Klaus F. Ley, Brendan Gongol, Miguel Alejandro Lopez‐Ramirez
This study identifies neuroinflammatory astrocytes and CCM endothelium interactions that drive leukocyte recruitment and immunothrombosis in cerebral cavernous malformations, while showing that targeting endothelial NF-kB may have harmful effects.
Circulation Research · Oct 26, 2022Peer-reviewedNeuroscience