Author

Catherine Chinhchu Lai

University of California San Diego

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Brendan GongoliD· 2 shared Hao SuniD· 2 shared Miguel Alejandro Lopez‐RamireziD· 2 shared Angela Pham· 1 shared Bliss NelseniD· 1 shared Eduardo Frías-AnayaiD· 1 shared Elan Ortiz· 1 shared Esau J. EstradaiD· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Brendan GongolORCID

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2 papers

Recent·Most cited

Neuroinflammation plays a critical role in cerebral cavernous malformation disease

Catherine Chinhchu Lai, Bliss Nelsen, Eduardo Frías-Anaya, Helios Gallego-Gutiérrez, Marco Orecchioni, Victoria Herrera, Elan Ortiz, Hao Sun, Omar A. Mesarwi, Klaus F. Ley, Brendan Gongol, Miguel Alejandro Lopez‐Ramirez

This study identifies neuroinflammatory astrocytes and CCM endothelium interactions that drive leukocyte recruitment and immunothrombosis in cerebral cavernous malformations, while showing that targeting endothelial NF-kB may have harmful effects.

Circulation Research · Oct 26, 2022Peer-reviewedNeuroscience

Non cell-autonomous effect of astrocytes on cerebral cavernous malformations

Miguel Alejandro Lopez‐Ramirez, Shady Ibrahim Soliman, Preston Hale, Catherine Chinhchu Lai, Angela Pham, Esau J. Estrada, Sara McCurdy, Romuald Girard, Riya Verma, Thomas Moore, Rhonda Lightle, Nicholas Hobson, Robert Shenkar, Orit Poulsen, Gabriel George Haddad, , Mark H. Ginsberg

The paper shows that astrocytes contribute to cerebral cavernous malformations (CCMs) through VEGF production driven by endothelial NO, highlighting non-cell-autonomous mechanisms.

bioRxiv · Jan 29, 2021 · PreprintNeuroscience