Bliss Nelsen

Behavioral impairments are linked to neuroinflammation in mice with Cerebral Cavernous Malformation disease

This study shows that CCM lesions in mice cause behavioral impairments linked to neuroinflammation, affecting motor coordination and memory.

Neuroinflammation plays a critical role in cerebral cavernous malformation disease

This study identifies neuroinflammatory astrocytes and CCM endothelium interactions that drive leukocyte recruitment and immunothrombosis in cerebral cavernous malformations, while showing that targeting endothelial NF-kB may have harmful effects.