Author

Marco Orecchioni

Augusta UniversityORCID 0000-0002-3602-8510Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Anna Christine Koebele· 1 shared Axel M. HillmeriD· 1 shared Bliss NelseniD· 1 shared Bodo LevkauiD· 1 shared Brendan GongoliD· 1 shared Catherine Chinhchu Lai· 1 shared Christian WeberiD· 1 shared Dennis MehrkensiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperImmunology

Anna Christine Koebele

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Olfactory receptor 2 drives abdominal aortic aneurysm by promoting CX3CR1-mediated monocyte recruitment

Patrik Schelemei, Felix S.R. Picard, Yein Park, Philipp Wollnitzke, Harshal Nemade, Dennis Mehrkens, Per Arkenberg, Anna Christine Koebele, Jan Wrobel, Kristel Martinez Lagunas, Elena Wagner, Henning Guthoff, Joy Roy, Moritz Lindquist Liljeqvist, Wiebke Ibing, , Holger Winkels

This study shows that Olfr2 promotes abdominal aortic aneurysm by enhancing CX3CR1-mediated monocyte recruitment through inflammatory pathways.

bioRxiv · Feb 28, 2025 · PreprintImmunology

Neuroinflammation plays a critical role in cerebral cavernous malformation disease

Catherine Chinhchu Lai, Bliss Nelsen, Eduardo Frías-Anaya, Helios Gallego-Gutiérrez, Marco Orecchioni, Victoria Herrera, Elan Ortiz, Hao Sun, Omar A. Mesarwi, Klaus F. Ley, Brendan Gongol, Miguel Alejandro Lopez‐Ramirez

This study identifies neuroinflammatory astrocytes and CCM endothelium interactions that drive leukocyte recruitment and immunothrombosis in cerebral cavernous malformations, while showing that targeting endothelial NF-kB may have harmful effects.

Circulation Research · Oct 26, 2022Peer-reviewedNeuroscience