Hepatitis C virus NS5A is not an effective antagonist of the canonical PKR-eIF2α pathway
Carla E. Gallardo-Flores, Lindsay L. Yu, Elana Kertzman, Paul Rothhaar, Volker Lohmann, Che C. Colpitts
This study shows that HCV NS5A does not inhibit the PKR-eIF2 pathway, contradicting previous claims and supporting that HCV replicates despite active PKR response.
bioRxiv · Oct 8, 2026 · PreprintMicrobiology