Volker Lohmann

The paper proposes a genetic divergence threshold for demarcating orthoflavivirus species, identifying 25 new Euflavivirus and 33 new Fusivirus species.

This study shows that HCV NS5A does not inhibit the PKR-eIF2 pathway, contradicting previous claims and supporting that HCV replicates despite active PKR response.

This study identifies a dimerization site in NS5A that enhances HCV replication fitness by promoting self-interaction, which inhibits NS3 and NS5B activity.

This study examines how HCV replication fitness affects antiviral treatment outcomes, finding that high replication fitness can compensate for resistance mutations and contribute to DAA treatment failure.

This study identifies bemnifosbuvir as a potent inhibitor of hepatitis E virus replication in vitro and in a gerbil model, with additive effects when combined with ribavirin.

The paper redefines the taxonomy of Flaviviridae by integrating protein sequence and structure data, revealing new clades and expanding host range.