Human-specific lncRNA TMEM9B-AS1 is downregulated in skeletal muscle of individuals with type 2 diabetes and regulates ribosomal biogenesis
Ilke Sen, Jonathon A. B. Smith, Elena Caria, Iurii A. Orlov, Mladen Savikj, Aidan J. Brady, Kristian Lian, Stian Ellefsen, Juleen Rae Zierath, Anna Krook
This study identifies TMEM9B-AS1, a human-specific lncRNA downregulated in type 2 diabetes skeletal muscle, which regulates ribosomal biogenesis by stabilizing MYC mRNA through interaction with IGF2BP1.
Science Advances · Jul 9, 2025Peer-reviewedCell Biology