Author

Mladen Savikj

Karolinska InstitutetORCID 0000-0002-9708-0750Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Anna KrookiD· 2 shared Jonathon A. B. SmithiD· 2 shared Juleen Rae ZierathiD· 2 shared Ahmed M. Abdelmoez· 1 shared Aidan J. BradyiD· 1 shared Brendan M. GabrieliD· 1 shared Elena Caria· 1 shared Ilke SeniD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCell Biology

Anna KrookORCID

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2 papers

Recent·Most cited

Human-specific lncRNA TMEM9B-AS1 is downregulated in skeletal muscle of individuals with type 2 diabetes and regulates ribosomal biogenesis

Ilke Sen, Jonathon A. B. Smith, Elena Caria, Iurii A. Orlov, Mladen Savikj, Aidan J. Brady, Kristian Lian, Stian Ellefsen, Juleen Rae Zierath, Anna Krook

This study identifies TMEM9B-AS1, a human-specific lncRNA downregulated in type 2 diabetes skeletal muscle, which regulates ribosomal biogenesis by stabilizing MYC mRNA through interaction with IGF2BP1.

Science Advances · Jul 9, 2025Peer-reviewedCell Biology

Downregulation of NR4A3 during inactivity alters glucose metabolism and impairs translation in human skeletal muscle

Jonathon A.B. Smith, Brendan M. Gabriel, Ahmed M. Abdelmoez, Mladen Savikj, Shane C. Wright, Stefania Koutsilieri, Romain Barrès, Volker M. Lauschke, Anna Krook, Juleen R. Zierath, Nicolas J. Pillon

This study shows that reduced NR4A3 levels in skeletal muscle due to inactivity impair glucose metabolism, translation, and myotube size by affecting mTORC1 and ribosomal pathways.

bioRxiv · Mar 11, 2024 · PreprintCell Biology