Anna Krook

Exercise intensity modulates the human plasma secretome and interorgan communication

This study examines how different exercise intensities affect the human plasma secretome and interorgan communication through multi-cohort interventions and multi-organ gene expression analysis.

Human-specific lncRNA TMEM9B-AS1 is downregulated in skeletal muscle of individuals with type 2 diabetes and regulates ribosomal biogenesis

This study identifies TMEM9B-AS1, a human-specific lncRNA downregulated in type 2 diabetes skeletal muscle, which regulates ribosomal biogenesis by stabilizing MYC mRNA through interaction with IGF2BP1.

miR-29a-3p, a new myokine orchestrating resistance exercise via coordinated metabolic responses

This study identifies miR-29a-3p as a myokine secreted during resistance exercise that coordinates metabolic responses and miRNA expression in muscle and liver.

Downregulation of NR4A3 during inactivity alters glucose metabolism and impairs translation in human skeletal muscle

This study shows that reduced NR4A3 levels in skeletal muscle due to inactivity impair glucose metabolism, translation, and myotube size by affecting mTORC1 and ribosomal pathways.