NNMT drives innate sensitivity to NAMPT inhibition in YAP-dependent stem-like/ mesenchymal prostate cancer
Ágata Sofia Assunção Carreira, Marianna Ciuffreda, Nathakan Thongon, Charles M. Haughey, Adam Pickard, Sharon L. Eddie, Rebecca E. Steele, Elena Cerri, Romina Belli, Daniele Peroni, Elisa Facen, Irene Caffa, Moustafa S. Ghanem, Alessio Nencioni, Andrea Lunardi, , Alessandro Provenzani
This study identifies the YAP/NNMT axis as a driver of innate sensitivity to NAMPT inhibition in stem-like mesenchymal prostate cancer, suggesting NNMT as a biomarker for NAD+-targeting therapies.
International Journal of Biological Sciences · Jan 1, 2026Peer-reviewedCancer Biology