Alessandro Provenzani

This study identifies the YAP/NNMT axis as a driver of innate sensitivity to NAMPT inhibition in stem-like mesenchymal prostate cancer, suggesting NNMT as a biomarker for NAD+-targeting therapies.

The paper uses structural biology and computational methods to design MSI-1 mutants that alter RNA binding selectivity, validated by NMR and SPR experiments.

This study investigates how TDP-43 dysregulation disrupts protein synthesis in ALS models by altering ribosome dynamics and mRNA homeostasis, revealing a conserved mechanism across in vitro and in vivo systems.

This study shows that tanshinone mimics inhibit HuR-RNA interactions, reducing LPS-induced inflammation in macrophages by decreasing cytokine and chemokine expression.

The paper identifies Tristetraprolin/ZFP36 as a regulator of HLA-DQ mRNA stability, specifically affecting celiac disease-associated alleles.