Cancer BiologybioRxivPreprint
EWS-FLI1 Expression in Human Embryonic MSCs Leads to Transcriptional Reprograming, Defective DNA Damage Repair and Ewing Sarcoma
Inmaculada Hernández‐Muñoz, Irene Cuervas, Estela Prada…·Jaume Mora
This study shows that EWS-FLI1 expression in human embryonic mesenchymal stem cells leads to an ES-like transcriptome and tumor formation, despite not preferentially binding promoters.