EWS-FLI1 Expression in Human Embryonic MSCs Leads to Transcriptional Reprograming, Defective DNA Damage Repair and Ewing Sarcoma
Inmaculada Hernández‐Muñoz, Irene Cuervas, Estela Prada, Julián Pulecio, Ramón Gimeno, Evelyn Andrades, Soledad Gómez‐González, Pau Berenguer‐Molins, Ariadna Acedo-Terrades, Júlia Perera‐Bel, Marta Bódalo‐Torruella, Lara Nonell, Elena Pérez, Daniela Grases, Caterina Mata, , Jaume Mora
This study shows that EWS-FLI1 expression in human embryonic mesenchymal stem cells leads to an ES-like transcriptome and tumor formation, despite not preferentially binding promoters.
bioRxiv · Jan 13, 2025 · PreprintCancer Biology