Double Stranded DNA Damage and Genome Editing Trigger Ribosome Remodeling and Translational Shutdown
Celeste Riepe, Elena Zelin, Stacia K. Wyman, David N. Nguyen, Jin Rui Liang, Phillip Andrew Frankino, Zuriah A. Meacham, Jonathan T. Vu, Alexander Marson, Nicholas T. Ingolia, Jacob E. Corn
This study shows that DNA double-strand breaks cause ribosome remodeling and translational shutdown, independent of p53 and preceding transcriptional changes.
bioRxiv · Dec 5, 2018 · PreprintMolecular Biology