Phillip Andrew Frankino

A non-canonical role for UPRER during heat stress in C. elegans.

This study shows heat stress activates UPRER through XBP-1 and HSF-1 in C. elegans, with cross-talk to cytosolic HSR and inter-tissue stress communication enhancing thermotolerance.

SKN-1 is a metabolic surveillance factor that monitors amino acid catabolism to control stress resistance

This study identifies SKN-1 as a metabolic surveillance factor that responds to amino acid catabolism to influence stress resistance in C. elegans.

Glia of C. elegans coordinate the heat shock response independent of the neuronal thermosensory circuit and serotonin

This paper shows that glia in C. elegans can induce a heat shock response in peripheral cells, increasing lifespan and stress resistance, independent of neurons and neurotransmitters.

Double Stranded DNA Damage and Genome Editing Trigger Ribosome Remodeling and Translational Shutdown

This study shows that DNA double-strand breaks cause ribosome remodeling and translational shutdown, independent of p53 and preceding transcriptional changes.