Muscle stem cells produce a protective Fibrillin-1 matrix to prevent precocious activation.
Eleni Chrysostomou, Oussama Smail, Artemis Vlachopoulou, Takuto Hayashi, Nicolas Tcheng, D. P. Reinhardt, Nicol Voermans, Frédéric Relaix, Philippos Mourikis
This paper identifies Fibrillin-1 as a Notch-regulated matrix protein that maintains muscle stem cell quiescence by shielding them from mitogenic signals, and shows its loss leads to muscle dysfunction in Marfan syndrome.
bioRxiv · Aug 2, 2025 · PreprintCell Biology