Philippos Mourikis

This study reveals metabolic heterogeneity in muscle stem cells and shows that their metabolism is regulated by adjacent myofibers in the niche.

This study shows that postnatal Pax7+ cells in limb muscles are multipotent, generating non-myogenic lineages like fibro-adipogenic progenitors that persist into adulthood and respond to injury.

This study identifies matrisome signatures in quiescent and activated muscle stem cells using transcriptomic data, linking ECM gene expression to niche function and muscle repair.

This paper identifies Fibrillin-1 as a Notch-regulated matrix protein that maintains muscle stem cell quiescence by shielding them from mitogenic signals, and shows its loss leads to muscle dysfunction in Marfan syndrome.