Frédéric Relaix

The paper identifies PAX3's role in coupling metabolism and cell mechanics during neuroepithelial morphogenesis, showing mannose metabolism is critical for adherens junction function.

This study reveals metabolic heterogeneity in muscle stem cells and shows that their metabolism is regulated by adjacent myofibers in the niche.

This study shows that postnatal Pax7+ cells in limb muscles are multipotent, generating non-myogenic lineages like fibro-adipogenic progenitors that persist into adulthood and respond to injury.

This study shows that SMN insufficiency in muscle stem cells leads to long-term motor neuron loss through non-cell autonomous mechanisms in SMA.

This study shows that transient hypoxia followed by reoxygenation is essential for skeletal muscle repair, mediated by Rev-ERBalpha regulation of myogenesis.

This study demonstrates that CRISPR/Cas13-mediated reduction of DNM2 expression can alleviate CNM symptoms in a canine model.

This paper identifies Fibrillin-1 as a Notch-regulated matrix protein that maintains muscle stem cell quiescence by shielding them from mitogenic signals, and shows its loss leads to muscle dysfunction in Marfan syndrome.

The paper shows glutaminase's non-canonical nuclear role in driving EMT during neural crest development by cooperating with Wnt signaling.

The paper shows PAX3/7 transcription factors use distinct gene networks to spatially control spinal cell fates through repression and activation mechanisms.

This study shows that glucose oxidation drives neural crest cell migration and fate decisions by mobilizing multiple metabolic pathways.

The paper identifies a fibroblast-to-myoblast conversion driven by BMP signalling at the muscle-tendon interface during limb development.