Christine E. Schnitzler

The paper describes a gene-agnostic FACS method to isolate stem cells from Hydractinia symbiolongicarpus using cellular stains and validates the population with cytology.

The paper updates and spatially validates a somatic single-cell atlas of Hydractinia symbiolongicarpus, identifying new cell types and developmental trajectories.

The paper identifies eight new stem cell markers in Hydractinia i-cells and shows their context-dependent expression, revealing transcriptional heterogeneity in the adult pluripotent stem cell population.

This study characterizes the genome and single-cell transcriptome of Hydractinia, revealing that its stem cells use a conserved gene toolkit shared with all animals.

This study shows that random genomic 6mA accumulation in early Hydractinia embryos delays zygotic transcription initiation by inhibiting gene expression.

This study identifies an XX/XY sex determination system in the cnidarian Hydractinia symbiolongicarpus, establishing it as a model for studying sex determination in non-bilaterian animals.

The paper identifies a family of immunoglobulin superfamily genes in the cnidarian Hydractinia symbiolongicarpus, showing they are homologous to vertebrate histocompatibility genes and suggest an ancient origin of V-set domains.

This study generates new Hydra genomes and transcriptomic resources to uncover conserved transcriptional regulatory mechanisms in cnidarians.

This study investigates SoxB-driven neurogenesis in the cnidarian Hydractinia symbiolongicarpus, showing sequential SoxB gene action and defects upon knockdown.

The paper develops an electroporation method to deliver shRNAs into Hydractinia embryos, enabling gene knockdown and phenotypic analysis.

This study maps stem cell differentiation trajectories in Hydra using single-cell transcriptomics, revealing shared progenitor states for neurons and gland cells and creating a gene expression map of the nervous system.

This paper introduces CRISPR/Cas9-mediated gene knockin in Hydractinia symbiolongicarpus, enabling stable transgene integration and germline transmission for functional genomics studies.