Identification of drug candidates for rescue of SOX17 gene targets in pulmonary arterial hypertension
Eleni Vasilaki, Bedia Akosman, Shanshan Song, Rachel Walters, Yamini Sharma, Mandy Pereira, Merve Keleş, Nadiya V Mykytyuk, Hannah Maude, Navneet Singh, George Field, Corey E. Ventetuolo, Luke Howard, Jurjan Aman, Martin R. Wilkins, , Christopher J. Rhodes
The paper identifies BX-912 as a compound that rescues SOX17 gene targets and prevents pulmonary hypertension in mice.
bioRxiv · May 21, 2026 · PreprintPharmacology & Toxicology