Corey E. Ventetuolo

Identification of drug candidates for rescue of SOX17 gene targets in pulmonary arterial hypertension

The paper identifies BX-912 as a compound that rescues SOX17 gene targets and prevents pulmonary hypertension in mice.

Impaired SOX17 Expression Causes Endothelial Dysfunction and Pulmonary Arterial Hypertension by Insufficient Suppression of RUNX1

This study shows that impaired SOX17 expression increases pulmonary arterial hypertension risk by failing to suppress RUNX1, leading to endothelial dysfunction, and that RUNX1 inhibition can mitigate this condition.

The Liver is an Inflammatory Mediator of Pulmonary Arterial Hypertension

This study identifies subclinical liver dysfunction clusters in PAH patients and links them to pulmonary vascular resistance and immune signaling changes.

Liver angiocrine myeloid-derived growth factor protects against endothelial dysfunction in pulmonary arterial hypertension

The paper investigates the role of hepatic MYDGF in pulmonary arterial hypertension, showing its protective effects in experimental models but paradoxical associations in human data.