Merve Keleş

KLF6 in Pulmonary Hypertension: The Dual Role of Friend and Foe

This study identifies KLF6 as a key driver of endothelial dysfunction in pulmonary arterial hypertension, showing its role in promoting vascular remodelling and angioproliferative lesions.

Identification of drug candidates for rescue of SOX17 gene targets in pulmonary arterial hypertension

The paper identifies BX-912 as a compound that rescues SOX17 gene targets and prevents pulmonary hypertension in mice.

Loss of cardiomyocyte eukaryotic elongation factor 1A2 in mice triggers cardiomyopathy due to defective proteostasis

This study shows that loss of eEF1A2 in cardiomyocytes causes cardiomyopathy through proteostasis defects, and mTORC1 inhibition can reverse the condition.

Endothelial cell-derived, secreted long non-coding RNAs Gadlor1 and Gadlor2 aggravate pathological cardiac remodeling via intercellular crosstalk

This study identifies Gadlor1 and Gadlor2 as endothelial cell-derived lncRNAs that worsen cardiac remodeling through EV-mediated crosstalk with cardiomyocytes.