Author

Mandy Pereira

Brown University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Bedia AkosmaniD· 2 shared Corey E. VentetuoloiD· 2 shared James R. KlingeriD· 2 shared Lan ZhaoiD· 2 shared Martin R. WilkinsiD· 2 shared Navneet SinghiD· 2 shared Olin D. LiangiD· 2 shared Yamini Sharma· 2 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPharmacology & Toxicology

Bedia AkosmanORCID

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2 papers

Recent·Most cited

Identification of drug candidates for rescue of SOX17 gene targets in pulmonary arterial hypertension

Eleni Vasilaki, Bedia Akosman, Shanshan Song, Rachel Walters, Yamini Sharma, Mandy Pereira, Merve Keleş, Nadiya V Mykytyuk, Hannah Maude, Navneet Singh, George Field, Corey E. Ventetuolo, Luke Howard, Jurjan Aman, Martin R. Wilkins, , Christopher J. Rhodes

The paper identifies BX-912 as a compound that rescues SOX17 gene targets and prevents pulmonary hypertension in mice.

bioRxiv · May 21, 2026 · PreprintPharmacology & Toxicology

Impaired SOX17 Expression Causes Endothelial Dysfunction and Pulmonary Arterial Hypertension by Insufficient Suppression of RUNX1

Bedia Akosman, Moon Jung Choi, Yamini Sharma, Mandy Pereira, Young Eun Lee, Eui Young So, Allyson Sherman‐Roe, Navneet Singh, Anthony M. Reginato, Corey E. Ventetuolo, Martin Wilkins, Lan Zhao, Christopher J. Rhodes, James R. Klinger, Olin D. Liang

This study shows that impaired SOX17 expression increases pulmonary arterial hypertension risk by failing to suppress RUNX1, leading to endothelial dysfunction, and that RUNX1 inhibition can mitigate this condition.

bioRxiv · May 15, 2026 · PreprintCell Biology