Pharmacology & ToxicologyNature CommunicationsPeer-reviewed
PRLX-93936 and BMS-214662 are cytotoxic molecular glues that leverage TRIM21 to degrade nucleoporins
Marc A Scemama de Gialluly, Anthony R. Allen, Elijah H Hayes…·Drew Adams
The paper identifies PRLX-93936 and BMS-214662 as molecular glues that use TRIM21 to degrade nucleoporins, leading to cell death and potential therapeutic applications in TRIM21-high cancers.
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