Author

Drew Adams

Case Western Reserve UniversityORCID 0000-0002-3038-336XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Organism:rat· 1

Frequent Co-Authors

Amanda N. FarrariD· 1 shared Anthony R. Allen· 1 shared Dharmaraja AllimuthuiD· 1 shared Elijah H Hayes· 1 shared Ilya R. BedermaniD· 1 shared Joel L. SaxiD· 1 shared Marc A Scemama de GiallulyiD· 1 shared Matthew S. ElittiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperPharmacology & Toxicology

Amanda N. FarrarORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologyNature CommunicationsPeer-reviewedJul 16, 2025

PRLX-93936 and BMS-214662 are cytotoxic molecular glues that leverage TRIM21 to degrade nucleoporins

Marc A Scemama de Gialluly, Anthony R. Allen, Elijah H Hayes…·Drew Adams

The paper identifies PRLX-93936 and BMS-214662 as molecular glues that use TRIM21 to degrade nucleoporins, leading to cell death and potential therapeutic applications in TRIM21-high cancers.

22 citationstop 2%

experimental assaydrug response / drug discovery

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NeuroscienceACS Chemical BiologyPeer-reviewedJul 14, 2022

Enhancers of human and rodent oligodendrocyte formation predominantly induce cholesterol precursor accumulation

Joel L. Sax, Samantha N. Hershman, Zita M L Hubler…·Drew Adams

This study identifies that many molecules promoting oligodendrocyte formation inhibit cholesterol pathway enzymes, with a focus on EBP, and proposes a model for their mechanism.

15 citations

humanmouse

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