Paul H. Huang

This study combines collagen-targeted IL-12 with doxorubicin to improve anti-tumor effects in osteosarcoma by enhancing tumor accumulation and immune activation.

This paper identifies HDAC inhibition as a strategy to overcome resistance to EZH2 inhibitors in INI1-deficient epithelioid sarcoma by restoring H3K27 acetylation and enhancing therapeutic response.

SCAN-ACT identifies and prioritizes T cell therapy targets for solid tumors using single-cell transcriptomics and multi-omics data, validating targets through experimental methods.

This study shows circulating tumor cells shed shearosome extracellular vesicles in capillary bifurcations, which activate endothelial and immune cells and contribute to pre-metastatic niche formation.