Myelin Supports Cortical Circuit Function Underlying Skilled Movement
Kimberly G. Gagnon, Gustavo Della Flora Nunes, Dailey Nettles, Thomas Nguyen, Elise Carter, Andreza Lins, W. Ryan Williamson, Jeremie Lefebvre, Daniel J. Denman, Ethan G. Hughes, Cristin G. Welle
This study shows that myelin loss impairs movement efficiency and alters neuronal activity, with partial remyelination restoring some network metrics but not smooth movement.
bioRxiv · Dec 24, 2025 · PreprintNeuroscience