Ethan G. Hughes

Activity-gated exocytosis drives myelin remodeling required for adult learning

This study identifies activity-dependent exocytosis in mature oligodendrocytes as a mechanism driving myelin remodeling necessary for adult learning.

Microglia drive demyelination via multiple sclerosis antibodies and BTK signaling

This study shows microglia drive myelin loss in MS through autoantibodies and BTK signaling, with implications for therapeutic targeting.

A myelinic channel system for motor-driven organelle transport

The paper identifies the myelinic channel system as a pathway for microtubule-dependent organelle transport in oligodendrocytes, showing its role in maintaining axonal integrity through neuronal activity and motor proteins.

Premyelinating Oligodendrocyte Survival Governs CNS Remyelination

This study shows that premyelinating oligodendrocyte survival affects oligodendrocyte production rates, with increased survival promoting regeneration after demyelination and decreased survival contributing to age-related decline.

Myelin Supports Cortical Circuit Function Underlying Skilled Movement

This study shows that myelin loss impairs movement efficiency and alters neuronal activity, with partial remyelination restoring some network metrics but not smooth movement.

Incomplete remyelination via endogenous or therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function

This study shows that partial oligodendrocyte restoration after demyelination is sufficient to recover visual cortical function in mice.

Paired vagus nerve stimulation drives precise remyelination and motor recovery after myelin loss

This study shows that paired vagus nerve stimulation promotes remyelination and motor recovery after myelin loss by restoring myelin sheath patterns.

Age-related myelin deficits in the auditory brain stem contribute to cocktail party-deficits

This study identifies age-related myelin deficits in the auditory brainstem pathway as a cause of spatial hearing deficits in aging Mongolian gerbils.

Long-term in vivo three-photon imaging reveals region-specific differences in healthy and regenerative oligodendrogenesis

This study uses three-photon imaging to show that white matter generates more oligodendrocytes than gray matter, but gray matter shows faster growth rates and regenerative deficits after injury.

Motor Learning Drives Dynamic Patterns of Intermittent Myelination onLearning-Activated Axons

The paper shows that learning induces dynamic changes in myelination on specific axons, altering conduction speed and correlating with behavioral improvement.

Characterization of red fluorescent reporters for dual-color in vivo three-photon microscopy

The paper evaluates tdTomato and mScarlet fluorescent proteins for dual-color three-photon microscopy in the mouse brain, finding high signal-to-background in specific wavelength ranges.

Motor Learning Promotes Remyelination via New and Surviving Oligodendrocytes

This study shows that motor learning after partial remyelination enhances remyelination by increasing oligodendrogenesis and myelin sheath generation.

Three dimensional two-photon imaging of neuronal activity in freely moving mice using a miniature fiber coupled microscope with active axial-scanning

This paper introduces a miniature two-photon microscope for 3D neuronal imaging in freely moving mice, demonstrating active axial scanning and multi-color fluorescence imaging.